Eosinophilic Esophagitis: An Emerging Disease in Childhood – Review of Diagnostic and Management Strategies

[摘要] Eosinophilic esophagitis is a chronic immune/antigen mediated inflammatory disease of the esophagus. It comprises a separate entity of increasing incidence and prevalence in children and adults. The disease is characterized by histological evidence of dense esophageal tissue eosinophilia in the presence of a variety of upper GI symptoms including vomiting, dysphagia, food impaction, and odynophagia. Cornerstone of treatment is dietary intervention and/or the off-label use of swallowed topical corticosteroids. New drug therapies are under investigation. In this review, we focus on the diagnostic approach and the currently available treatment strategies.

[学科分类] 儿科学

[关键词] eosinophilic esophagitis;oral viscous budesonide;fluticasone propionate;oral steroids;amino acid-based formula;empiric elimination diet;targeted elimination diet