Hepatoblastoma: A Need for Cell Lines and Tissue Banks to Develop Targeted Drug Therapies

[摘要] Limited research exists regarding the most aggressive forms of hepatoblastoma. Cell lines of the rare subtypes of hepatoblastoma with poor prognosis are not only difficult to attain but also challenging to characterize histologically. A community-driven approach to educating parents and families, regarding the need for donated tissue, is necessary for scientists to have access to resources for murine models and drug discovery. Herein, we describe the currently available resources, existing gaps in research, and the path to move forward for uniform cure of hepatoblastoma.

[学科分类] 儿科学

[关键词] hepatoblastoma;roadmap;xenograft models;cell lines;tissue procurement