Androgen Receptor Expression in Primary Nonsquamous Cell Rare-Variant Carcinomas of the Head and Neck:

[摘要] ObjectiveAndrogen receptor (AR) is a diagnostic immunohistochemical marker for salivary gland duct carcinoma (SDC), but other nonsquamous cell head and neck carcinomas (NSCCs) may also express it. The aim of this preliminary study was to investigate the immunohistochemical expression of AR in rare head and neck NSCCs.Study DesignRetrospective analysis of histologic records.SettingA large community hospital.Subjects and MethodsTwenty-seven patients with NSCC were selected (21 men, 6 women; average age, 69 years). Exclusion criteria were histologically confirmed primary and metastatic head and neck squamous cell carcinomas and thyroid carcinomas. AR immunohistochemistry was done on formalin-fixed, paraffin-embedded tissue blocks.ResultsVariable AR expression was found in 5 of 27 (25%) cases of NSCC. All 7 patients with SDC showed intense and extensive positive immunoreactivity. Of 27 NSCC tumors, 15 (56%) had negative staining.ConclusionIn the head and neck, expression of AR is not limited to SDCs; other NS...

[学科分类] 外科医学

[关键词] head;neck;nonsquamous cell carcinoma;rogen receptor;immunohistochemistry;preliminary study