血液透析中不同时间注射低分子肝素钠的抗凝效果

[摘要] Abstract：Objective To investigate the anticoagulation effect of low molecular heparin sodium with different administration time in hemodialysis patients. Methods Totally 30 hemodialysis patients were assigned to the Group A, Group B and Group C, with 10 cases in each group. The patients were treated with low molecular heparin sodium 60 IU/kg at 0 min(Group A), 15minutes(Group B)and 30 minutes(Group C)after onset of hemodialysis. The coagulation situation in hemodialysis pipelines and dialyzer was observed. The activated partial thromboplastin time(APTT), prothrombin time(PT), transmembrane pressure, venous dialysis pressure and compression time of puncture point were compared between groups. Results  Patients in Group C had a less severity of coagulation in hemodialysis pipelines and dialyzer compared with those in Group A and Group B(P<0.05). The APTT and PT of patients were longer 4 hours after onset of hemodialysis, but with no significant difference among three groups(P>0.05). There was no significant difference in transmembrane pressure, venous dialysis pressure and compression time of puncture point among three groups(P>0.05). Conclusion  The low molecular heparin sodium 60 IU/kg administrated 30 minutes after hemodialysis onset shows a sound c anticoagulation effect in hemodialysis pipelinesand dialyzer.

[学科分类] 护理学

[关键词] 低分子肝素钠;血液透析;终末期肾功能衰竭;凝血;凝血酶原时间