Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients

[摘要] Background. Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker of chronic inflammation and is considered to be a risk factor for coronary artery disease (CAD) in Caucasians. This study investigated the role of suPAR in young Chinese patients with CAD. Methods. The study involved a total of 196 consecutive young (age???55 years) patients with angiographically proven CAD and 188 age-matched non-CAD individuals as controls. Traditional risk factors were evaluated using conventional assays, and levels of suPAR were measured by sandwich enzyme-linked immunosorbent assays. Results. Levels of suPAR were significantly correlated with age (r=0.20, P=0.04), smoking (r=0.33, P=0.008), body mass index (r=0.21, P=0.03), and high-sensitivity C-reactive protein (hs-CRP; r=0.31, P=0.01). Multivariate logistic regression analysis showed that male sex (odds ratio (OR)?=?3.12; 95% confidence interval (CI)?=?1.18–8.25, P=0.02), smoking (OR?=?3.41, 95% CI?=?1.55–7.50, P=0.002), triglyceride (OR?=?1.89, 95% CI?=?1.10–3.25, P=0.02), high-sensitivity C-reactive protein (OR?=?1.24, 95% CI?=?1.02–0.03, P=0.03), and suPAR (OR?=?1.37, 95% CI?=?1.09–1.72, P=0.007) were independently associated with CAD risk in young patients. Conclusions. SuPAR is a novel independent risk factor for CAD in young Chinese patients. Further studies evaluating the effect of anti-inflammatory treatment on the suPAR levels and the risk of CAD are needed.

[学科分类] 生理学与病理学