Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea

[摘要] Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%). Prevalence of subclinical hypothyroidism was significantly higher in OSA hypertensives than in non-OSA ones (15.0% versus 6.9%, P=0.014). Serum LnTSH in hypertensives with severe OSA was significantly higher (0.99±0.81 versus 0.74±0.77??IU/mL, P<0.05) than in those without OSA. AHI, LSaO2, ODI3, and ODI4 were independently associated with serum TSH for those aged 30–65 years. Dividing subjects into four groups as TSH < 1.0??IU/mL, 1.0 ? THS ? 1.9??IU/mL, 1.91 ? TSH < 4.5??IU/mL, and TSH ? 4.5??IU/mL, only 26.3% of OSA subjects exhibited TSH between 1.0 and 1.9??IU/mL, significantly less than non-OSA subjects (26.3% versus 38.2%, P=0.01). DBP and serum LDL-c elevated with TSH increasing and were only significantly higher in TSH ? 4.5??IU/mL group than in 1.0 ? TSH ? 1.9??IU/mL group (96.32±14.19 versus 92.31±12.86?mmHg; P=0.040; 0.99±0.60 versus 0.87±0.34?mmol/L, P=0.023). Conclusion. OSA might be a risk factor for increased TSH even within reference range in hypertensive population.

[学科分类] 内分泌与代谢学