Incidence of anaphylactic reactions after propofol administration indogs

[摘要] Propofol is an anesthetic agent suspended in an emulsion system that includes egg yolklecithin and soybean oil, because of which, there is concern about the use of propofol inpatients allergic to these substances. We examined the association between propofoladministration and incidence of adverse events in dogs with allergy to egg yolk lecithinand soybean oil. On the basis of the findings of an allergen-specific immunoglobulin E(IgE) test, 14 dogs with high levels (high-IgE group) and 7 dogs with low levels(normal-IgE group) of IgE were selected. Following intravenous administration of propofol,the incidence of anaphylactic reactions and plasma histamine concentrations under generalanesthesia maintained with isoflurane throughout surgery were compared between the twogroups. The frequency of anaphylactic reactions and plasma histamine concentrations werecompared by the chi-square test and Student t-test, respectively. Thestatistical significance for both tests was set at P<0.05. In thehigh- and normal-IgE groups, the average frequencies of anaphylactic reactions afterpropofol administration were 21.4 and 14.3%, and the mean plasma histamine concentrationswere 167.9 ± 94.5 nM and 65.7 ± 40.3 nM, respectively. Animals of neither groupsexperienced shock-like symptoms. These results revealed that propofol might be relativelysafe, although careful perioperative anesthesia monitoring and standby protocols arerequired when using propofol in dogs with a history of allergic diseases or high chicken-or soybean-specific IgE levels.

[学科分类] 兽医学

[关键词] anesthesia;dog;histamine;immunoglobulin-E;propofol-induced anaphylaxis