Hodgkin’s-like lymphoma in a ferret (Mustela putoriusfuro)

[摘要] A 7-year-old castrated male ferret developed unilateral cervical lymphadenomegaly over a1-month period. Histological examination revealed proliferation of tumor cells in adiffuse and partially nodular pattern. The tumor cells were predominantly Hodgkin cellsand binucleated Reed-Sternberg cells, characterized by abundant, clear, vacuolatedcytoplasm, pleomorphic, ovoid nuclei with thick nuclear membranes and distinct nucleoli.Multinucleated cells, resembling lymphocytic and histiocytic (L&H) cells, were alsoobserved. Immunohistochemically, the tumor cells expressed Pax-5, BLA-36 and vimentin. Asmall population of the tumor cells expressed CD20. This case showed proliferation ofHodgkin/Reed-Sternberg cells in conjunction with L&H cells that were histologicallyanalogous to feline Hodgkin’s-like lymphoma. However, Pax-5 and BLA-36 expression alongwith rare CD20 expression were consistent with classical Hodgkin’s lymphoma in humans.

[学科分类] 兽医学

[关键词] ferret;Hodgkin’s-like lymphoma;Reed-Sternberg cell