Effect of burdock extract on physical performance and physiological fatiguein mice

[摘要] Burdock (BD) is a common vegetable with many pharmacological properties. However, fewstudies have examined the effect of BD on exercise performance and physical fatigue. Weaimed to evaluate the potential beneficial effects of BD on fatigue and ergogenicfunctions following physical challenge in mice. Methods Male ICR mice were divided intofour groups to receive either vehicle, or BD at 348.5, 697 or 1,742.5 mg/kg/day, by dailyoral gavage for 4 weeks. Exercise performance and fatigue were evaluated from forelimbgrip strength, exhaustive swimming time, and post-exercise levels of physicalfatigue-related biomarkers serum lactate, ammonia, glucose, and creatine kinase (CK).Results BD supplementation elevated endurance and grip strength in a dose-dependentmanner. It also significantly decreased lactate, ammonia, and CK levels after physicalchallenge. In addition, BD supplementation had few subchronic toxic effects. ConclusionsSupplementation with BD has a wide spectrum of bioactive effects, including healthpromotion, performance improvement, and fatigue reduction.

[学科分类] 兽医学

[关键词] anti-fatigue;burdock;endurance;grip strength;toxicity