Adverse effects of maternal exposure to bisphenol F on the anxiety- anddepression-like behavior of offspring

[摘要] Bisphenol A (BPA), a well-known endocrine disruptor, is metabolized and eliminatedrapidly from the body in adult animals. However, many authors have reported that perinatalBPA exposure alters development of the brain, reproductive system and behavior in the nextgeneration. Recently, BPA substitutes, especially bisphenol F (BPF), have been usedbecause of concerns about the influence of BPA on children, although the actual effects onthe next generation are unknown. In this study, we observed behavioral adverse effects ofthe offspring of mice exposed to BPA or BPF in fetal period. Female C57BL/6 mice weregiven oral BPA or BPF (0 or 10 mg/kg body weight) daily from gestational day 11.5 to 18.5.The open field test, the elevated plus maze test and the forced swim test were performedat postnatal week 10. BPF exposure altered offspring behavior significantly, resulting inincreases in anxiety and depressive state. The influence of BPF was stronger than that ofBPA. We demonstrated novel evidence that BPF influences the behavior of offspring.

[学科分类] 兽医学

[关键词] anxiety behavior;bisphenol A;bisphenol F;depression;endocrine disruptors