Serum levels of ochratoxin A in dogs with chronic kidney disease (CKD): aretrospective study

[摘要] Ochratoxin A (OTA) is a mycotoxin produced by secondary metabolism of several fungibelonging to the genera Aspergillus and Penicillium. OTAis potentially nephrotoxic, neurotoxic, immunotoxic and carcinogenic in several animalspecies and in humans. This toxin has been detected in several human food and animal feed.The aim of this study was to determine OTA in blood samples of healthy and affected bychronic kidney disease (CKD) dogs. CKD group showed higher incidence of OTA-positivitythan healthy dogs (96 vs. 56%) and a significantly higher median value of OTA plasmaconcentration (0.008 vs. 0.144 ng/ml).No significant correlation was observed between OTA levels and creatinine values in CKDdogs. This is the first study regarding OTA detection in plasma samples of healthy and CKDdogs; the presence of this toxin is higher in nephropatic patients but is not yet clear,if it is correlated with progression of the disease.

[学科分类] 兽医学

[关键词] chronic kidney disease;dog;nephrotoxin;ochratoxin A