Expression of epithelial cell-derived cytokine genes in the duodenal andcolonic mucosae of dogs with chronic enteropathy

[摘要] It remains unclear whether epithelial cell-derived cytokines, including interleukin(IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development ofcanine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE),food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the presentstudy, we examined mRNA expression of il-25, il-33 andtslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD.Real-time PCR analysis revealed that mRNA expression of il-33 wassignificantly lower in the duodenum in dogs with FRE than in healthy dogs. The resultssuggest that epithelial cell-derived cytokines may not be an inducer of Th2-type immunityin the gut of dogs with CE, and decreased expression of IL-33 may be involved in inductionof FRE. Further studies are required to clarify roles of epithelial cell-derivedcytokines, especially IL-33, in the pathogenesis of canine CE.

[学科分类] 兽医学

[关键词] chronic enteropathy;dog cytokines;epithelial cell-derived cytokines;food-responsive enteropathy;inflammatory bowel disease