Royal jelly improves hyperglycemia in obese/diabetic KK-Aymice

[摘要] The study examined whether royal jelly (RJ) can prevent obesity and amelioratehyperglycemia in type 2 diabetes. This study utilized obese/diabetic KK-Ay mice. RJ (10mg/kg) was administered by oral gavage. Body weight, plasma glucose and insulin levelswere measured. mRNA and protein levels were determined using quantitative reversetranscription polymerase chain reaction and western blotting, respectively. Four weeks ofRJ administration improved hyperglycemia and partially suppressed body weight gain,although the latter effect did not reach statistical significance. In addition, RJadministration did not improve insulin resistance. RJ administration suppressed the mRNAexpression of glucose-6-phosphatase (G6Pase), a key enzyme ofgluconeogenesis, in the liver. Simultaneously, RJ administration induced adiponectin(AdipoQ) expression in abdominal fat, adiponectin receptor-1(AdipoR1) expression in the liver and phosphorylated AMP-activatedprotein kinase (pAMPK) expression, which suppressed G6Pase levels in the livers of KK-Aymice. pAMPK levels were also increased in skeletal muscle, but glucose transporter-4(Glut4) translocation was not increased in the RJ supplementation group. The improvementin hyperglycemia due to long-term RJ administration may be because of the suppression ofG6Pase expression through the upregulation of AdipoQ andAdipoR1 mRNA and pAMPK protein expressions.

[学科分类] 兽医学

[关键词] diabetes;hyperglycemia;KK-Ay mice;royal jelly