Partial exposure of frog heart to high-potassium solution: an easilyreproducible model mimicking ST segment changes

[摘要] By simply inducing burn injuries on the bullfrog heart, we previously reported a simplemodel of abnormal ST segment changes observed in human ischemic heart disease. In thepresent study, instead of inducing burn injuries, we partially exposed the surface of thefrog heart to high-potassium (K+) solution to create a concentration gradientof the extracellular K+ within the myocardium. Dual recordings of ECG and thecardiac action potential demonstrated significant elevation of the ST segment and theresting membrane potential, indicating its usefulness as a simple model of heart injury.Additionally, from our results, Na+/K+-ATPase activity was thoughtto be primarily responsible for generating the K+ concentration gradient andinducing the ST segment changes in ECG.

[学科分类] 兽医学

[关键词] bullfrog heart;ischemic heart disease;Na+/K+-ATPase activity;partial exposure to high-potassium solution;ST segment change