Remifentanil decreases oral tissue blood flow while maintaining internalcarotid artery blood flow during sevoflurane anesthesia in rabbits

[摘要] The aim of this study was to investigate the effect of remifentanil infusion on oraltissue blood flow including submandibular gland tissue blood flow (SBF) and internalcarotid artery blood flow (ICBF) in rabbits during sevoflurane anesthesia. Twelve maleJapan White rabbits were anesthetized with sevoflurane and remifentanil. Remifentanil wasinfused at 0.2 and 0.4 µg/kg/min. Measurements included circulatoryvariables, common and external carotid artery blood flow (CCBF, ECBF), ICBF, tonguemucosal blood flow (TMBF), masseter muscle tissue blood flow (MBF), mandibular bone marrowtissue blood flow (BBF), tongue muscle tissue blood flow (TBF) and SBF. Vascularresistances for each tissue, including the tongue mucosa, masseter muscle, mandibular bonemarrow, tongue muscle and submandibular gland, were calculated by dividing the meanarterial pressure by the respective tissue blood flow. Remifentanil infusion decreasedoral tissue blood flow and circulatory variables. CCBF, ECBF and ICBF did not change. Thecalculated vascular resistance in each oral tissue, except for the tongue mucosa,increased in an infusion-rate-dependent manner. These results showed that remifentanilinfusion reduced TMBF, MBF, BBF, TBF and SBF in an infusion-rate-dependent manner withoutaffecting ICBF under sevoflurane anesthesia.

[学科分类] 兽医学

[关键词] internal carotid artery blood flow;oral tissue blood flow;remifentanil;sevoflurane