Genetic factors affecting intraoperative 5-aminolevulinic acid-induced fluorescence of diffuse gliomas

[摘要] BackgroundIn patients operated for malignant glioma, 5-aminolevulinic acid (5-ALA)-induced fluorescence guidance is useful. However, we occasionally experience instances of non-visible fluorescence despite a histopathological diagnosis of high-grade glioma. We sought to identify factors that influence the intraoperative visualization of gliomas by their 5-ALA-induced fluorescence.

[学科分类] 肿瘤学

[关键词] glioma;5-aminolevulinic acid (5-ALA);IDH1 mutation