The influence of genetic variability on the risk of developing malignant mesothelioma

[摘要] BackgroundMalignant mesothelioma is a rare cancer with poor outcome, associated with asbestos exposure. Reactive oxygen species may play an important role in the mechanism of carcinogenesis; therefore, genetic variability in antioxidative defence may modify an individual’s susceptibility to this cancer. This study investigated the influence of functional polymorphisms of NQO1, CAT, SOD2 and hOGG1 genes, gene-gene interactions and gene-environment interactions on malignant mesothelioma risk.

[学科分类] 肿瘤学

[关键词] antioxidative enzymes;genetic polymorphism;malignant mesothelioma