Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation

[摘要] An efficient and ecofriendly method for the synthesis of disubstituted 5-aminopyrimidines from vinyl azides and urea or thiourea was developed. This reaction proceeds under microwave irradiation conditions in the presence of water as a solvent. The remarkable features of this new protocol are high conversion, short reaction times, cleaner reaction profiles and straightforward procedure.

[学科分类] 化学（综合）

[关键词] Green chemistry;disubstituted 5-aminopyrimidines;vinyl azide;water;microwaves