Synthesis of functionalized 4H-Chromenes catalyzed by lipase immobilized on magnetic nanoparticles

[摘要] In the work, mucor miehei lipase (MML) was covalently immobilized on the 2,4,6-trichloro-1,3,5-triazine (TCT)-modified magnetite nanoparticles. Then, the immobilized MML was utilized in the synthesis of functionalized 4H-Chromenes via a multicomponent reaction firstly. Under the optimized reaction conditions, immobilized MML displayed high catalytic performance (Yield: 81–96%) and excellent reusability, indicating a high potential for practical operation.

[学科分类] 化学（综合）

[关键词] Lipase;multicomponent;magnetic nanoparticle;immobilization;4H-chromene