Follow-up of Chronic HBV Infected Patients Planned Chemotherapy Due to Solid Organ Malignancy

[摘要] The aim of this study was to screen the patients with solid organ malignancy for HBV (Hepatitis B virus) infection before the start ofchemotherapy and follow up in the oncology department of our setting. All cases admitted to oncology department for chemotherapywere screened prospectively for HBV infection and reactivation between March 2013-September 2014. A total of 225 patients wereincluded in the study and divided into 3 groups; Group I: having recovered past HBV infection: 43 patients (19.1%), Group II: isolatedAnti-HBcAg total positive: 20 patients (8.9%) and Group III: chronic HBV infection with 10 patients (4.4%). HBV reactivation developedin one (5.9%) of 17 patients in group II, and two (28.6%) of seven patients in group III while under lamivudine prophylaxis. Neitherhepatitis flare by HBV reactivation nor HBV-related death were observed in our study. In the moderate endemicity areas like Turkeyfor HBV infection, all patients must be screened for HBV before starting of chemotherapy.

[学科分类] 肿瘤学

[关键词] Chemotherapy;HBV Reactivation;Solid Cancer