Anticuerpos anticitomegalovirus y antivirus de Epstein Barr en pacientes cubanos en espera de trasplante hematopoyético

[摘要] Secondary complications due to infections caused by Cytomegalovirus (CMV) and Epstein Barr virus (EBV) are the major infectious causes of morbidity and mortality in recipients of hematopoietic stem cell (HSC) grafts. Detection of specific antibodies against each of those viruses in the pre-transplant period allows the prevention of the primary infection during the immune suppressive therapy.The aim of the investigation was to determine seroprevalence of antibodies against CMV and EBV and also to identify the patients in risk of a primary infection in the post-transplant period.The investigation was conducted between January 2013 and January 2016 by the Histocompatibility Department of Instiute of Hematology and Immunology. Antibodies IgM and IgG against CMV and EBV were tested by ELISA in 110 patients with the indication for histocompatibility testing for a HSC graft.Seroprevalence of antibodies against CMV in this population was 84.5% and seroprevalence of antibodies against EBV was 90.9%. The 70.6% of children less than 9 years old had positive IgG CMV antibodies and the 64.7% of them had positive IgG EBV antibodies. An increase of seroprevalence with age was found. The seroprevalence of antibodies against CMV and EBV in patients waiting for a HSC transplant in Cuba is similar to the populations in other countries. This result suggests the need of avoiding the transmissiontoseronegative recipients.

[学科分类] 生理学与病理学

[关键词] antibody;anti-CMV;anti-EBV;human leukocyte antigens;major histocompatibility complex;hematopoietic stem cell transplantation.