Wound Healing Activity of Ethanolic Extract of Scutellaria barbata D. Don (Lamiaceae) Leaves Extract in Excision and Burn Wound Models

[摘要] Objective: To evaluate the wound healing effect of ethanolic extract of Scutellaria barbata D(Lamiaceae) in rats. Methods: Male Sprague Dawley rats weighing 250–300 g were randomly divided into incision and burn wound groups. Each group was stratified into three subgroups (1) untreated; (2) standard-; (3) test (extract) treated groups. The test substances were applied topically once daily. The general appearance and degree of wound healing were assessed on Days 4, 8, 12, 16 and 20 after burns and excision wound. The parameters studied were percentage of wound contraction and period of epithliazation in excision and burn wound model. Histopathological evaluation was carried out. Results: In excision and burn wound model, a significant decrease in period of epithelialisation was observed in all the treatment groups compared to the control group. Comparative analysis revealed that the plant extract Scutellaria barbata D. Don (10%) shows wound healing activity. There was significant reduction of wound contraction in the Standard Povidone Iodine Treatment group and standard Silver Sulphadiazine group. Histopathological findings on Day 21 revealed prominent fibrinoid necrosis and incomplete epithelialization in the control groups, whereas fully developed epithelialization and keratinization were observed in all extract-treated groups. Conclusion: Ethanolic extract of Scutellaria barbata D(Lamiaceae) was found to possess significant wound healing property in both excision and burn wound models.

[学科分类] 药理学

[关键词] Kiran C Nilugal P;Santosh Fattepur;Mohd Fadli Asmani;Ibrahim Abdullah;Vicky Aw Yong;Ug;ar RE;Scutellaria barbata D;Wound healing;Excision wound;Burn wound