Polymorphism in the structure of N-(5-methyl­thia­zol-2-yl)-4-oxo-4H-chromene-3-carboxamide

[摘要] Chromone derivatives have been extensively studied recently because of to their promising biological activities. The new title chromone–thia­zole hybrid presented here, C14H10N2O3S, is a candidate as a selective ligand for adenosine receptors. The compound has been synthesized and characterized by the usual spectroscopic means (NMR and EM/IE) and its structure elucidated by X-ray crystallography, which revealed the presence of packing polymorphism. The two polymorphs (one with space group P21/n and one with P21/c) show slightly different conformations and the major change induced by crystallization regards the intra­molecular contacts defining the supra­molecular structure. Those differences been highlighted by Hirshfeld surface analysis mapped over dnorm and ESP.

[学科分类] 数学（综合）

[关键词] CRYSTAL STRUCTURE;DRUG DESIGN;CHROMONES;CONFORMATION;SUPRAMOLECULAR STRUCTURE