Impact of sleep disordered breathing on short-term post-operative outcome after elective coronary artery bypass graft surgery: a prospective observational study

[摘要] Sleep disordered breathing (SDB) is common in patients with coronary disease; but its impact on post-operative recovery after coronary artery bypass graft surgery (CABG) is unclear. We therefore determined the effects of SDB on post-operative outcome after elective CABG.In this prospective two-centre study; 219 patients due to receive elective CABG underwent cardiorespiratory polygraphy for SDB prior to surgery and were monitored for post-operative complications. The primary end-point was a composite of 30-day mortality or major post-operative complications (cardiac; respiratory; surgical; infectious; acute renal failure or stroke). Key secondary end-points were single components of the primary end-point.SDB was present in 69% and moderate/severe SDB in 43% of the CABG patients. There was no difference in the composite of 30-day mortality or major postoperative complications between patients with and without SDB (OR 0.97; 95% CI 0.49xe2x80x931.96) and between patients with moderate/severe SDB and no/mild SDB (OR 1.07; 95% CI 0.55xe2x80x932.06). However; moderate/severe SDB was associated with higher rates of mortality (crude OR 10.1; 95% CI 1.22xe2x80x9383.5); sepsis (OR 2.96; 95% CI 1.17xe2x80x937.50) and respiratory complications (OR 2.85; 95% CI 1.46xe2x80x935.55).Although SDB was not associated with higher overall morbidity/mortality; moderate/severe SDB may increase the risk of death; and septic and respiratory complications; after elective CABG.

[学科分类] 呼吸医学