Screening for pulmonary arterial hypertension in an unselected prospective systemic sclerosis cohort

[摘要] Screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) improves outcomes. The DETECT screening algorithm is recommended in a high-risk SSc subgroup. This study aims to compare prospectively the positive predictive value of screening using the DETECT algorithm and the 2009 European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines; and to compare their cost-effectiveness in an unselected; day-to-day SSc population. Post hoc; screening according to the 2015 ESC/ERS guidelines using echocardiographic parameters alone (xe2x80x9c2015 echo screeningxe2x80x9d) or combined with the DETECT algorithm (xe2x80x9c2015 combined screeningxe2x80x9d) in high-risk subjects was analysed.195 consecutive SSc patients included in the Ghent University Hospital SSc cohort were screened using different algorithms.The referral rate for right heart catheterisation was 32% (63 out of 195 patients) (46/4/13/34/40 patients using the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). Right heart catheterisation was performed in 53 patients (84%) (36 (78%)/four (100%)/13 (100%)/28 (82%)/32 (80%) patients recommended by the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). PAH was diagnosed in three patients (incidence 1.5%xc2xb7yearxe2x80x931; 95% CI 0.5xe2x80x934.4); in whom all algorithms recommended a right heart catheterisation. The positive predictive value was 6% (95% CI 2xe2x80x9317%; three out of 49 patients) for the DETECT algorithm; 18% (95% CI 6xe2x80x9341%; three out of 17 patients) for the 2009 guidelines; 23% (95% CI 8xe2x80x9350%; three out of 13 patients) for both; 11% (95% CI 4xe2x80x9327%; three out of 28 patients) for the 2015 echo screening and 9% (95% CI 3xe2x80x9324%; three out of 32 patients) for the 2015 combined screening. The cost was EUR224/80/90/112 per patient using the DETECT algorithm/2009 guidelines/2015 echo screening/2015 combined screening.Echocardiography may remain a candidate first step for PAH screening in SSc.

[学科分类] 呼吸医学