Differences between asthmaxe2x80x93COPD overlap syndrome and adult-onset asthma

[摘要] Differences between asthmaxe2x80x93COPD overlap syndrome (ACOS) and adult-onset asthma are poorly understood. This study aimed to evaluate these differences in a clinical cohort of patients with adult-onset asthma; as a part of the Seinxc3xa4joki Adult Asthma Study (SAAS).188 patients were diagnosed with adult-onset asthma and re-evaluated 12xe2x80x85years after diagnosis. They were divided into three groups based on smoking history and post bronchodilator spirometry values: 1)xc2xa0never- and ex-smokers with <10 smoked pack-years; 2) non-obstructive (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) xe2x89xa50.7) patients with xe2x89xa510 pack-years; and 3) ACOS patients with xe2x89xa510 pack-years and FEV1/FVC <0.7.ACOS patients had lower diffusing capacity (DLCO/VA 86% predicted versus 98 or 96% predicted; p<0.001); higher blood neutrophil levels (4.50 versus 3.60 or 3.85xc3x97109 Lxe2x88x921; p=0.008); and higher IL-6 levels (2.88 versus 1.52 or 2.10xe2x80x85pgxc2xb7mLxe2x88x921; p<0.001) as compared to never- and ex-smokers with <10 pack-years; or non-obstructive patients with xe2x89xa510 pack-years smoking history; respectively. ACOS patients also showed reduced lung function; higher remaining bronchial reversibility and a higher number of comorbidities.This study shows distinct differences in diffusing capacity; blood neutrophil and IL-6 levels; bronchial reversibility; lung function and comorbidities between ACOS and adult-onset asthma. The present findings should be considered in the comprehensive assessment of adult asthma patients.

[学科分类] 呼吸医学