Physical activity, airway resistance and small airway dysfunction in severe asthma

[摘要] ExtractAsthma is a chronic airway disease with a heterogeneous clinical presentation [1]; and a subset of xe2x88xbc5xe2x80x9310% of patients suffer from severe disease [2]. Chronic obstructive pulmonary disease (COPD) is different from asthma with respect to underlying pathobiology but shares some clinical features with severe asthma; for instance fixed airway obstruction and small airway dysfunction [3; 4]. In COPD; the consequences of the disease for physical activity in daily life have been studied intensively [5xe2x80x937]; in contrast; only few data are available on patients with asthma [8]. Measurements of physical activity in adult patients with stable asthma of different severity grades are lacking; and associations with airway physiology have not been evaluated.

[学科分类] 呼吸医学