A meta-analysis of genome-wide association studies of asthma in Puertoxc2xa0Ricans

[摘要] Puerto Ricans are disproportionately affected with asthma in the USA. In this study; we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans.We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans; including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II; the Hartfordxe2x80x93Puerto Rico Study and the Hispanic Community Health Study. Moreover; we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans.The only locus to achieve genome-wide significance was chromosome 17q21; as evidenced by our top single nucleotide polymorphism (SNP); rs907092 (OR 0.71; p=1.2xc3x9710xe2x88x9212) at IKZF3. Similar to results in non-Puerto Ricans; SNPs in genes in the same linkage disequilibrium block as IKZF3 (e.g. ZPBP2; ORMDL3 and GSDMB) were significantly associated with asthma in Puerto Ricans. With regard to results from a meta-analysis in Europeans; we replicated findings for rs2305480 at GSDMB; but not for SNPs in any other genes. On the other hand; we replicated results from a meta-analysis of North American populations for SNPs at IL1RL1; TSLP and GSDMB but not for IL33.Our findings suggest that common variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans.

[学科分类] 呼吸医学