Long-term change in reactance by forced oscillation technique correlates with FEV1 decline in moderate COPD patients

[摘要] ExtractSince the landmark study of the natural history of chronic obstructive pulmonary disease (COPD) by Fletcher and Peto [1]; lung function decline has been an issue of great concern and an important therapeutic target. The annual decline in forced expiratory volume in 1xe2x80x85s (FEV1) is generally used as a marker of disease progression. A review of large longitudinal studies found that the mean rate of FEV1 decline was highest at Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II (47xe2x80x9379xe2x80x85mLxc2xb7yearxe2x88x921); indicating the need for treatment at earlier stages of the disease [2].

[学科分类] 呼吸医学