Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice

[摘要] ExtractObstructive sleep apnoea (OSA) is a very prevalent disorder with well proven mid- and long-term deleterious consequences; such as increased risk of cardiovascular; metabolic and neurocognitive diseases [1]. Recently; considerable data from both animal models and patient studies also suggest that OSA increases the risk of cancer incidence and mortality [2]. Some of these studies indicate that nocturnal hypoxic events experienced by OSA patients as a consequence of recurrent upper airway obstructions may be a main challenge driving tumour progression [3; 4]. Although the clinical and experimental data available do not undoubtedly prove a relationship between cancer and OSA [5]; its plausibility has raised the interest of basic and clinical researchers in the field; warranting further investigation [6].

[学科分类] 呼吸医学