Prospective study of insomnia and incident asthma in adults: the HUNT study

[摘要] Insomnia is highly prevalent among asthmatics; however; few studies have investigated insomnia symptoms and asthma development. We aimed to investigate the association between insomnia and the risk of incident asthma in a population-based cohort.Among 17xe2x80x8a927 participants free from asthma at baseline we calculated odds ratios and 95% confidence intervals for the risk of incident asthma among those with insomnia compared to those without. Participants reported sleep initiation problems; sleep maintenance problems and nonrestorative sleep. Chronic insomnia was defined as those reporting one or more insomnia symptom at baseline and 10xe2x80x85years earlier. Incident asthma was defined by questions on asthma at baseline and follow-up (average 11xe2x80x85years).The prevalence of sleep initiation problems; sleep maintenance problems and nonrestorative sleep were 1%; 1% and 5%; respectively. The multi-adjusted odds ratios were 1.18 (95% CI 0.97xe2x80x931.44); 1.30 (95% CI 1.03xe2x80x931.64) and 1.70 (95% CI 1.37xe2x80x932.11) for people with one; two and three insomnia symptoms; respectively; compared with people without symptoms (p<0.01 for trend). The risk of developing asthma in those with chronic insomnia was three times higher (adjusted OR 3.16; 95% CI 1.37xe2x80x936.40) than those without.Insomnia symptoms were associated with increased risk of incident asthma in this study.

[学科分类] 呼吸医学