Mechanistic studies on chemical instabilities of recombinant proteins

[摘要] (cont.) Combining the information obtained from the previous two approaches, force was calculated along the reaction coordinate direction that was determined and verified previously. This information was integrated into a reaction rate model in order to compute the reaction rate constants. The computational results show that the mechano-chemical mechanism can yield reasonable rate constants comparable with available experimental data.

[发布机构] Massachusetts Institute of Technology