Is Hypercalcemic Diet A Possible Antidote To Oral Contraceptive-Induced Hypertension?

[摘要] Administration of oral contraceptive (OC) has been associated with body fluid retention and in high doses over a long period, promotes hypertension (Oelkers 1996). This present investigation tests the hypothesis that the dietary calcium supplementation increases salt and water excretion in OC (norgestre/ethinylestradiol) treated 32 female albino rats randomly distributed into four (1-4) groups of 8 rats each: Control, OC-treated, OC-treated+ Calcium diet fed and Calcium diet fed only respectively. OC was administered to the appropriate groups by gavage. Experimental diet contained 2.5% calcium supplement. Plasma and urinary [Na

[学科分类] 内科医学

[关键词] Hypercalcemic-diet, Oral contraceptive, Plasma electrolytes, Hypertension, Female-albino-rats