Thyroid hormone receptor-mediated transcription is suppressed by low dose Phthalate

[摘要] Phthalates are synthetic chemicals used mainly as solvents, additives and plasticizers in polyvinylchloride (PVC) products to increase their flexibility. Phthalate plasticizers are not chemically bound to PVC, so they easily leach into the environment. There is currently heightened concern about potential health risk, especially endocrine disrupting effects associated with the use of these chemicals. We therefore investigated the effects of phthalate on thyroid hormone receptor (TR)-mediated transcription using transient transfection studies and found that low dose phthalate (10

[学科分类] 内科医学

[关键词] Phthalate;Thyroid hormone;Thyroid hormone receptor;Transcription