Effect of Methamidophos on cerebellar neuronal cells

[摘要] Methamidophos is a toxic organophosphorus compound that inhibits acetlycholinesterase activity, and induces neurotoxicity. It is a synthetic chemical commonly used as pesticides to limit pest damages to cultivated plants. Currently, there is serious public health concern over its safety and use due to its global nature, persistence and bioaccumulations. We have previously reported that methamidophos suppressed thyroid hormone receptor (TR)-mediated transcription, but did not dissociate the interaction between TR and its response element (thyroid hormone response element; TRE), neither did it interact with nuclear cofactors. In the present study, we investigated the effects of methamidophos on cerebellar neuronal cells. Using primary cerebellar culture from new born rats, We observed that Purkinje cell dendrite arborization were greatly impaired in the absence of thyroid hormone (TH), However, low dose methamidophos 10

[学科分类] 内科医学

[关键词] Methamidophos;Thyroid hormone;Purkinje Cells;Granule cell;Neuronal development