Maytansinoid immunoconjugate IMGN901 is cytotoxic in a three-dimensional culture model of multiple myeloma
[摘要] Environmental-mediated drug-resistance (EM-DR) presents a major challenge for therapeutic development. Tissue microenvironment in the form of extracellular matrix, soluble factors, and stroma contribute to EM-DR. In multiple myeloma (MM), drug-resistance
[发布日期] [发布机构]
[效力级别] [学科分类] 血液学
[关键词] Multiple myeloma;environment-mediated drug resistance;tumor-stromal interactions;extracellular matrix;MDR-1 [时效性]
