DNA methylation and genetic polymorphisms of the Leptin gene interact to influence lung function outcomes and asthma at 18 years of age
[摘要] The leptin gene (LEP) plays a regulatory role in satiety； inflammation； and allergy. Prior findings linking leptin to asthma motivated us to investigate whether DNA methylation (DNA-M) of CpG (cytosine-phosphate-guanine) sites in concert with single nucle
[发布日期] [发布机构]
[效力级别] [学科分类] 流行病学
[关键词] Epigenetics； CpGs； SNPs； spirometry； FEV1； FEV1/FVC ratio； FEF25-75%； asthma [时效性]
