Phosphodiesterase-5 inhibition suppresses colonic inflammation-induced tumorigenesis via blocking the recruitment of MDSC

[摘要] Phosphodiesterase 5 (PDE-5) is a major isoform of cGMP phosphodiesterase in diverse tissues and plays a critical role in regulating intracellular cGMP concentrations. However； the distribution and expression of PDE-5 in colitis-related colon cancer was st

[学科分类] 肿瘤学

[关键词] Colon cancer； colitis； PDE-5； Sildenafil； MDSC