Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma

[摘要] We report a case of a recurrent clear cell meningioma (ccm) in the frontal lobe of the brain of a 67-year-old man. The patient developed three recurrences: at 3, 10, and 12 years after his initial surgery. Histopathology observations revealed a grade 2 ccm with positivity for vimentin and epithelial membrane antigen. Expression of E-cadherin was positive only in the primary tumour and in the first available recurrence. Fluorescencein situhybridization analyses demonstrated 1p and 14q deletions within the last recurrence. Multiplex ligation-dependent probe amplification studies revealed a heterozygous partialNF2gene deletion, which progressed to total loss in the last recurrence. The last recurrence showed homozygous deletions inCDKN2AandCDKN2B.TheRASSF1gene was hypermethylated during tumour evolution.In this report, we show the genetic alterations of a primary ccm and its recurrences to elucidate their relationships with the changes involved in the progression of this rare neoplasm.

[学科分类] 肿瘤学

[关键词] Clear cell meningioma;recurrence;intracranial disease;non-pediatric disease;genetics;NF2;tumour suppressor genes;molecular progression