Effect of Beta-Blockers on Number of Osteoblasts and Osteoclasts in Alveolar Socket Following Tooth Extraction in Wistar Rats

[摘要] Statement of the Problem:Various researchers have suggested the use of β2-adrenergic receptor antagonists in prevention or treatment of bone resorption. Purpose:This study aimed to evaluate the effect of β2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extraction socket of maxillary first molar in rats. Materials and Method:Maxillary first molars of 40 rats were extracted and divided into two groups. The test group received 0.1 mg/kg propranolol intraperitoneally daily. The controls received normal saline. At days 7, 14, 21 and 28 post-extraction, 5 rats were euthanized from each group. Maxillary bone was resected and the mean number of osteoblasts and osteoclasts in tooth socket was measured. Results:After 1 week, the number of osteoclasts in the controls was significantly higher than the test group. A significant increase in the number of osteoclasts in both groups at week 1 was observed compared to the following weeks ( p < 0.05). The number of osteoblasts in the controls at second week reached its maximum rate but stayed constant in the 3 rdand 4 thweeks. Osteoblasts in the test group increased similar to the controls but reached its maximum at 3 rdweek and showed a significant increase compared to the controls ( p < 0.05). Conclusion:β2 adrenergic receptor antagonists decrease the number of osteoclasts and increase the number of osteoblasts during extraction socket healing.  Keywords ●Osteoclast ●Osteoblast ●Propranolol ●Alveolar bone ●Rat

[学科分类] 口腔科学

[关键词] Osteoclast ;Osteoblast ;Propranolol ;Alveolar bone ;Rat