Cardiorespiratory alterations in rodents experimentally envenomed with Hadruroides lunatus scorpion venom

[摘要] Hadruroides lunatus is the most abundant scorpion species in the Peruvian central coast, where most of the accidents involving humans are registered. In spite of its prevalence, there are only very few studies on H. lunatus envenomation. The aim of the present study was to analyze the cardiorespiratory alterations caused by H. lunatus envenomation in rodents. Wistar rats injected with H. lunatus scorpion venom were submitted to electrocardiography. After euthanasia, rat lungs were collected and histopathologically analyzed. Mouse cardiomyocytes were used to perform immunofluorescence and calcium transient assays. Data were analyzed by ANOVA or Student’s t-test. The significance level was set at p 

[学科分类] 药理学

[关键词] Hadruroides lunatus venom;Cardiorespiratory alterations;Electrocardiography;Immunofluorescence;Calcium transient