PROTECTIVE EFFECT OF NERIUM INDICUM ON CCl4 INDUCED HEPATOTOXICITY IN RATS

[摘要] Methanolic flowers extract of Nerium indicum was evaluated for hepatoprotective in rats. The plant extract (500 and 1000 mg/kg, p.o.) showed a remarkable hepatoprotective activity against carbon tetrachloride induced hepatotoxicity in liver tissues. Carbon tetrachloride induced a significant rise in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT) and alkaline phosphatase (ALP). Treatment of rats with different doses of plant extract (500 and 1000 mg/kg) significantly (P<0.001) altered serum marker enzymes levels to against carbon tetrachloride treated rats. The activity of the extract at dose of 300 mg/kg was comparable to the standard drug, silymarin (100 mg/kg, p.o.). Histopathological changes of liver sample were compared with respective control. Results indicate the hepatoprotective properties of Nerium indicum against carbon tetrachloride induced hepatotoxicity in rats.

[学科分类] 基础医学

[关键词] Nerium indicum;Hepatoprotective activity;carbon tetrachloride