DEVELOPMENT, EVALUATION, AND OPTIMIZATION OF GELLAN GUM BASED IN SITU GEL USING 32 FACTORIAL DESIGNS

[摘要] Among oral dosage form, liquid dosage forms are more prone to low bioavailability because of their quick transit from the gastrointestinal tract. Sustained release liquid formulation with efficacy can be produced using approach of In situ gel. The purpose of the present work was to develop oral in situ gelling system using Gellan gum for in situ gelation of ambroxol-HCl.  The formulation variables like concentration of polymer and calcium chloride will be optimized using factorial design. Optimized formulations were prepared having desirability and evaluated for various parameter.

[学科分类] 基础医学

[关键词] Gellan gum;sustain release;optimization