A randomized trial of Intraarticular bupivacaine and bupivacaine with clonidine for postoperative analgesia after arthroscopic knee surgery

[摘要] Alpha-2-adrenergic agonists have peripheral analgesic effect, We have assessed the potential analgesic effect of intraarticular clonidine after intraarticular administration in arthroscpic knee surgery.Intraarticular (IA) local anaesthetics are often used for the management and prevention of pain after artheroscopic knee surgery. Clonidine an ?2 agonist prolongs the duration of local anaeshtetics. We designed this study to determine whether clonidine added to an IA injection would result in an analgesic benefit. We evaluated 60 patients undergoing arthroscopic knee surgery under spinal anaesthesia. After surgery patients were randomly assigned into two groups. Group B received 20ml of 0.25% bupivacine IA. Group C received 20ml of 0.25 bupivacaine along with 1g/kg BW of clonidine. The study revealed a significant difference in analgesia from the IA administration of clonidine. Patients in group C had a significantly decreased need for postoperative analgesia and increased analgesic duration.Keywords: Intraarticular, Arthroscopy, Clonidine Bupivacaine .postoperatve analgesia

[学科分类] 基础医学

[关键词] Intraarticular;Arthroscopy;Clonidine Bupivacaine .postoperatve analgesia