Evaluation of the effect of typical or Atypical Antipsychotic drug on sexual function in men with schizophrenia

[摘要] Sexual dysfunction secondary to antipsychotics may decrease the quality of life and therefore is an important item for measuring outcomes. Studies have reported different prevalence of sexual side effects caused by antipsychotic. The aim of this study was to evaluate the effects of typical and atypical antipsychotic drugs on sexual function in men with schizophrenia. A total of 98 schizophrenia men using typical and atypical antipsychotic drugs referred to Farabi Hospital of Kermanshah in 2016 enrolled in the study and BMSFI sexual function questionnaire was completed. The data then entered into SPSS statistical software (version 21) and the scores of each item and total scores were compared between two groups. To analyze the data, the statistical frequency, percentage, mean and standard deviation of test t-test was used. Of the 98 men enrolled in the study, 54 patients treated with typical, and 44 patients were treated with atypical antipsychotics. Sixty-seven men from 98 patients (68.36 percent) had sexual dysfunction. By comparing the average variations in the scores between typical and atypical drugs, a significant difference was only observed in terms of sexual desire between the two groups. But in other areas of sexual dysfunction did not differ significantly between two treatment groups. According to the results of this study, the prevalence of sexual dysfunction in schizophrenic patients treated with antipsychotic drugs is high. So, psychiatrists for treatment of psychological disease, particularly schizophrenia should consider sexual function and change the medication to control it to improve the patient's quality of life, if necessary.

[学科分类] 药理学

[关键词] Faezeh Tatari;Vahid Farnia;Atena Samadi;Mostafa Alikhani;seyed Mohsen Hojatkhah;sexual dysfunction;schizophrenia;typical antipsychotic drugs;atypical antipsychotic Drugs