Formulation and Evaluation of Hydralazine Hydrochloride Fast Dissolving Tablets by Sublimation Method In the Treatment of Pregnancy Induced Hypertension

[摘要] Solid dosage forms also have a impervious difficulties in patients especially for geriatric and paediatric patients.Dysphagia is common among all age groups.Fastdissolving tablets constitute an inventive dosage form that overcome the problems swallowing and provides speedy onset of action.The objective of present study was to formulate FDTs of Hydralazine HCL by sublimation method. Formulation of FDTs of Hydralazine HCL were prepared by using various superdisintegrants and volatile ingredients. The formulas were evaluated for compatibility, Pre-compression studies and post compression studies. Optimised formula was subjected to stability studies.Among all the formulations SF9 showed effective percentage of drug release at 12 minutes.

[学科分类] 药理学

[关键词] MUTHUKUMAR S;SUNDARA GANAPATHY R;Fast dissolving tablet;Pregnancy induced hypertension (Eclampsia;preeclampsia);Hydralazine Hydrochloride;sublimation method.