Synergistic effect of selected Hydroxy cinnamic acid derivative (HCA) with rivastigmine in Dementia

[摘要] Alzheimer’s disease (AD) is the most common form of dementia. AD is a progressive and irreversible neurodegenerative disease, which damages and kills brain cells. Expand Design: the study was designed to evaluate the anti choline esterase inhibitory property of selected HCA derivative and observe its effects on AlCl3 induced dementia in rats. The four compounds Cinnamic acid, Protocatechuic acid, Sinapic Acid and Rosmarinic acid were tested for in vitro choline esterase activity and based on the results, and reported literature protocatechuic acid was selected to test in animals. Dementia was induced by aluminium chloride at a dose of 175mg/kg, p.o. for a period of 25 days in rats and then divided into five different groups, i.e. rivastigmine, negative control and to see their additive effects two other groups were divided, which received rivastigmine (1.25mg/kg. p.o+ 50 mg/kg PCA, p.o) and last group received PCA (50mg/kg, p.o), where these groups treated and observed until the 35 day of experimental trial. The different behavioral and biochemical parameters were determined during or end of experiment. Results: Aluminium chloride in a dose of 175mg/kg, o.p. significantly induced the dementia and PCA acid, at a dose of 50 mg/kg, p.o., possessed potentially useful protective effect against Aluminium chloride induced-dementia of AD type in rats and provide additive effects when given with rivastigmine

[学科分类] 药理学

[关键词] Qin Zheng1;Wenjun Sun1;Miao Qu1*;Souravh Bais2;Dementia;Aluminium;rivastigmine;Alzheimer’s disease;dichloromethane