The Golgi Apparatus: Panel Point of Cytosolic Ca2+ Regulation

[摘要] The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca²⁺ store because different Ca²⁺ regulators, such as the inositol-1,4,5-triphosphate receptor, sarco/endoplasmic reticulum Ca²⁺-ATPase and secretory pathway Ca²⁺-ATPase, were demonstrated to localize on their membrane. The mechanisms involved in Ca²⁺ release and uptake in the GA have now been established. Here, based on careful backward looking on compartments and patterns in GA Ca²⁺ regulation, we review neurological diseases related to GA calcium remodeling and propose a modified cytosolic Ca²⁺ adjustment model, in which GA acts as part of the panel point.

[学科分类] 神经科学

[关键词] Ca2+ regulators;Cytosolic calcium;Golgi apparatus;Intracellular calcium store