Hemodynamic fluid shear stress response genes and carotid intima-media thickness: a candidate gene association analysis in the cardiovascular health study

[摘要] ObjectiveThis study examined whether carotid artery intimal-medial thickness (cIMT) is associated with genetic variations (SNPs) in a hemodynamics-responsive gene pathway.

[学科分类] 流行病学

[关键词] Cardiovascular Health Study (CHS);candidate gene study;carotid intima-media thickness (cIMT);hemodynamics response;fluid shear stress;endothelium / endothelial cells;Kruppel-like factor 2 (KLF2);Mitogen-activated protein kinase 7 (MAPK7);Myocyte-specific enhancer factor 2 A/C (MEF2A/C);Mitogen-activated protein kinase kinase 5 (MAP2K5)