Местное применение 0,05% циклоспорина А в качестве вспомогательной терапии при LASIK

[摘要] Purpose.To study topical 0.05% cyclosporine A as an adjunct to LASIK in patients with a high percentage of altered (corneal) tissue (PAT) and, consequently, with a high susceptibility risk to the post-LASIK dry eye syndrome. Material and methods . This study included 23 patients (48 eyes) with PTA≥0.4 (40%) ((PTA=(PFT+CAD)/PCT, PFT – predicted flap thickness, CAD – calculated ablation depth, PCT – preoperative corneal thickness). The patients were divided into 2 study groups: (1) standard postoperative treatment and an additional topical 0.05% cyclosporine A (3 months preoperatively and within 1 month postoperatively) and (2) standard postoperative treatment. Instability of surface regularity index (ISRI), tear production and corneal sensitivity were estimated 90±10 days preoperatively and 30±3 days postoperatively. Results.There was no statistically significant difference in ISRI, tear production and corneal sensitivity between the study groups at initial control point of investigation 90±10 days preoperatively. In the follow-up period of 30±3 days postoperatively the dynamics to an ISRI increase, a reduction of tear production and corneal sensitivity compared to preoperative values was detected in both groups. The ISRI was significantly higher in the group 2 compared to the group 1 (0.37±0.06 and 0.28±0.07, respectively, p=0.017), the tear production was significantly lower in the group 2 compared to group 1 (11.4±2.7mm and 13.8±3.6mm, respectively, p=0.021), the corneal sensitivity was significantly lower in the group 2 compared to the group 1 (34.9±5.7mm and 48.2±6.6mm, respectively, p=0.003). Conclusion . The topical application of 0.05% cyclosporine A as an pre- and post-operative adjunct to LASIK in the patients with the high PAT value (≥0.4 (40%)) reduces a severity of symptoms of post-LASIK dry eye syndrome.

[学科分类] 眼科学

[关键词] LASIK;dry eye syndrome;cyclosporine;corneal flap;ablation depth;LASIK;синдром «сухого глаза»;циклоспорин;роговичный лоскут;глубина абляции